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Friday, 24 August 2012

HIV/ AIDS


Human Immuno Deficiency virus infection/ acquired immunodeficiency syndrome (HIV/ AIDS) is a disease of the human immune system caused by Human Immunodeficiency virus(HIV)

TRANSMISSION:
  • HIV is transmitted primarily via unprotected sexual intercourse, contaminated blood transfusion and hypodermic needles,and from mother to child during pregnancy,delivery or breast feeding
  • some body fluids such as saliva and tears do not transmit HIV
  • prevention of HIV infection primarily through safe sex and needle exchange programs is a key strategy to control the disease
PATHOPHYSIOLOGY:
  • The PATHOPHYSIOLOGY of aids is complex.
  • ultimately HIV causes AIDS by depleting CD4+ T cells.
  • This weakens the immune system and allows opportunistic infection(infections caused by pathogens).
  • Tcells are essential to the immune response and without them the body cannot fight infections (or) kill cancerous cells.
  • thus weakening of CD4 T cells mainly includes the function of HIV virus
DIAGNOSIS:
HIV infection is commonly diagnosed by blood tests. there are three main types of tests that are commonly used
  1. HIV antibody test
  2. RNA tests
  3. combination test that detects both antibodies and a piece of the virus called P24 protien
These are the referred symptoms for aids and the details are as follows:
  • ENCEPHALITIS is an acute inflammation of brain which can be observed by noticing the patient in a confused state and can be diagnosed by testing the brain
  • MENINGITIS is the inflammation of the protective membranes of brain and spinal cord
  • RETINITIS is the viral infection of retina which results in blurred vision and blindness
  • PNEUMOCYSTIS pneumonia is a type of pneumonia caused by yeast like fungus and mostly effects the condition of lungs
  • esophagitis is the infection of esophagus
The most commonly used medication for aids is
Brand NameDrug Names (INN)Date of FDA ApprovalCompany
Combivirzidovudine + lamivudineSeptember 26, 1997GlaxoSmithKline
Trizivirabacavir + zidovudine + lamivudineNovember 15, 2000GlaxoSmithKline
Kaletralopinavir + ritonavirSeptember 15, 2000Abbott Laboratories
Epzicom (in USA)
Kivexa (in Europe)
abacavir + lamivudineAugust 2, 2004GlaxoSmithKline
Truvadatenofovir/emtricitabineAugust 2, 2004Gilead Sciences
Atriplaefavirenz + tenofovir/emtricitabineJuly 12, 2006Gilead Sciences and
Bristol-Myers Squibb

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